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Looking back I guess the incorporation of psychoneuro-immunology (PNI) into an expanded biopsychosocial model of health and wellness reflects the essence of my life’s work. Going forward it is my contention that PNI will need to be recognized in a post-Covid era as a critical element in the support of wellness and an integral part of intervention in regard to illness. Herewith is a recent interview which I believe captures the essence of the subject.